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In the present study, we evaluated the association of the <i>BAT1</i>, <i>NFKBIL</i>, <i>LTA</i>, and <i>CASP1</i> single nucleotide polymorphisms and the gene–gene interactions with risk of developing restenosis after coronary stenting. The allele and genotype determination of the polymorphisms (<i>BAT1</i> rs2239527 <i>C</i>/<i>G</i>, <i>NFKBIL1</i> rs2071592 <i>T</i>/<i>A</i>, <i>LTA</i> rs1800683 <i>G</i>/<i>A</i>, <i>CASP1</i> rs501192 <i>A</i>/<i>G</i>, and <i>CASP1</i> rs580253 <i>A</i>/<i>G</i>) were performed by 5’exonuclease TaqMan assays in 219 patients: 66 patients with restenosis and 153 without restenosis. The distribution of rs2239527 <i>C</i>/<i>G</i>, rs2071592 <i>T</i>/<i>A</i>, and rs1800683 <i>G</i>/<i>A</i> polymorphisms was similar in patients with and without restenosis. Nonetheless, under recessive (OR = 2.73, pC_Res = 0.031) and additive models (OR = 1.65, pC_Add = 0.039), the <i>AA</i> genotype of the rs501192 <i>A</i>/<i>G</i> polymorphism increased the restenosis risk. Under co-dominant, dominant, recessive, and additive models, the <i>AA</i> genotype of the rs580253 A/G was associated with a high restenosis risk (OR = 5.38, pC_Co-Dom = 0.003; OR = 2.12, pC_Dom = 0.031; OR = 4.32, pC_Res = 0.001; and OR = 2.16, 95%CI: 1.33–3.52, pC_Add = 0.001, respectively). In addition, we identified an interaction associated with restenosis susceptibility: <i>BAT1-NFKBIL1-LTA-CASP1</i> (OR = 9.92, <i>p</i> < 0.001). In summary, our findings demonstrate that the rs501192 <i>A</i>/<i>G</i> and rs580253 <i>A</i>/<i>G</i> polymorphisms, as well as the gene–gene interactions between <i>BAT1-NFKBIL1-LTA-CASP1</i>, are associated with an increased restenosis risk after coronary stenting.