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AIM:To observe the clinical efficacy of laser photocoagulation combined with compound xueshuantong capsule on the treatment of retinal vein occlusion.<p>METHODS: Sixty-four patients with retinal vein occlusion were randomly divided into laser photocoagulation treatment group(control group, <i>n</i>=32)and laser photocoagulation combined with compound xueshuantong capsule treatment group(observation group, <i>n</i>=32). The visual acuity, macular thickness and clinical effective rate of the two groups were observed and compared. <p>RESULTS:The total clinical effective rate and the proportion of visual improvement of the observation group were significantly higher than those of the control group, and the differences between the two groups were statistically significant(<i>P</i><0.05 or <i>P</i><0.01); The macular thickness at 1, 3, 6mo after the treatment of the two groups were significantly lower than those before the treatment(<i>P</i><0.05), and macular thickness at 1, 3, 6mo after the treatment of the observation group were significantly lower than those of the control group at the same period(<i>P</i><0.05). <p>CONCLUSION:Laser photocoagulation combined with compound xueshuantong capsule has a good effect in treating retinal vein occlusion, which can effectively improve visual acuity, reduce macular thickness, and deserves further study.