Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges
oleh: Alan J. Simmons, Ken S. Lau
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-01-01 |
Deskripsi
An impediment to the understanding of cancer is the heterogeneous nature of cell populations within a tumor microenvironment. We reported a method to query protein signaling in single epithelial cells from formalin-fixed paraffin-embedded (FFPE) colorectal cancer tissues. Here, we discuss the feasibility and limitations of this approach for investigating signaling state heterogeneity.