HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
oleh: Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT browning.