Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral <i>Briareum excavatum</i> (Briareidae)
oleh: Thanh-Hao Huynh, Lee-Shing Fang, Yu-Hsin Chen, Bo-Rong Peng, You-Ying Chen, Li-Guo Zheng, Yu-Jen Wu, Zhi-Hong Wen, Jih-Jung Chen, Tzu-Chi Lin, Ping-Jyun Sung
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2020-03-01 |
Deskripsi
Five 8,17-epoxybriaranes, including three new compounds—briarenols I−K (<b>1</b>−<b>3</b>), along with two known analogues, briaexcavatolide P (<b>4</b>) and briaexcavatin P (<b>5</b>), were isolated from the octocoral <i>Briareum excavatum</i>. The structures of briaranes <b>1</b>−<b>3</b> were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane <b>4</b> exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.