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Zika virus is a mosquito-borne flavivirus that is becoming a new global threat. Currently, serologic (ELISA) and molecular (RT-PCR) testing make the diagnosis of Zika virus infection. There is no specific drug available for Zika virus infection, and treatment is supportive based on reducing symptoms of disease. Protection against mosquito bites is the most effective way to prevent the infection. In this systematic review, all of the English published papers on Zika virus were assessed before December 2017, and were overviewed. Bibliographic databases had searched including; PubMed, Scopus, Google scholar, and Science Direct by using the keywords such as; “Zika virus”, “Zika fever”, and “Zika infection”. In this review, the pathogenesis, epidemiology, clinical features, transmission, laboratory diagnosis, treatment, and prevention of Zika virus infection were discussed