Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase
oleh: Gang Liu, Debangsu Sil, Nunziata Maio, Wing-Hang Tong, J. Martin Bollinger, Carsten Krebs, Tracey Ann Rouault
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-12-01 |
Deskripsi
Heme biosynthesis depends on iron-sulfur (Fe-S) cluster biogenesis but the molecular connection between these pathways is not fully understood. Here, the authors show that the heme biosynthesis enzyme ALAD contains an Fe-S cluster, disruption of which reduces ALAD activity and heme production in human cells.