Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function
oleh: Zehua Bian, Qiang Wang, Xinyu Zhou, Tao Tan, Ki Ho Park, H. Fritz Kramer, Alan McDougal, Nicholas J. Laping, Sanjay Kumar, T. M. Ayodele Adesanya, Matthew Sermersheim, Frank Yi, Xinxin Wang, Junwei Wu, Kristyn Gumpper, Qiwei Jiang, Duofen He, Pei-Hui Lin, Haichang Li, Fangxia Guan, Jingsong Zhou, Mark J. Kohr, Chunyu Zeng, Hua Zhu, Jianjie Ma
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-10-01 |
Deskripsi
MG53 is a protein that regulates the cell membrane repair process, and it’s been suggested that it might play a role in diabetes. Here, the authors demonstrate that circulating MG53 functions as a myokine to facilitate tissue injury-repair and regeneration without impacting glucose handling.