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Hantavirus, which is seen globally, is a zoonotic pathogen that causes severe clinical pictures such as fever, thrombocytopenia-related hemorrhages and acute renal failure in humans. Their natural hosts are rodents, insectivorous animals and bats. Mild encephalitis/encephalopathy with a reversible splenial lesion, in which many viral infections including Hantavirus play a role in the etiology, is an encephalitis/encephalopathy condition. In this case report, it was aimed to draw attention to the rapidly progressing and mortal Hantavirus infection.