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This article concerns the existence and uniqueness of a time periodic solution for the non-isentropic quantum hydrodynamic equations with viscosity. By applying the Leray-Schauder theory, subtle energy estimates and a limiting method, we obtain the existence of time periodic solutions under some smallness assumptions on the time periodic external force in $\mathbb{R}^3$. The uniqueness can be proved by similar energy estimates. In particular, the quantum effects and the energy equation are taken into account in this paper which play a significant role in the uniform (in the domain R and the positive constant $\epsilon$) estimates, especially in the selection of the norm.