Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice
oleh: M. Rizzi, K. Powell, M. R. Robinson, T. Matsuki, J. Hoke, R. N. Maswood, A. Georgiadis, M. Georgiou, P. R. Jones, C. Ripamonti, F. M. Nadal-Nicolás, M. Michaelides, G. S. Rubin, A. J. Smith, R. R. Ali
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Treatments to rescue vision are currently limited. Here, the authors identify a cone-driven gain control mechanism that reduces visual function beyond the atrophic area in humans. They also show that activating laterally projecting cells results improved vision in two mouse models of retinal degeneration.