Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation
oleh: Zhaoting Liu, Guozhu Ning, Ranran Xu, Yu Cao, Anming Meng, Qiang Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-08-01 |
Deskripsi
It is unclear how the cytoskeleton acts to assist in TGF-β signalling downstream of the receptor. Here, in zebrafish, the authors show that the actin-bundling protein FSCN1 interacts with TGF-β type I receptors ALK 4 and 5, enabling actin filament mediated vesicle trafficking and endoderm formation.