Structural basis for Ca2+-dependent activation of a plant metacaspase
oleh: Ping Zhu, Xiao-Hong Yu, Cheng Wang, Qingfang Zhang, Wu Liu, Sean McSweeney, John Shanklin, Eric Lam, Qun Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Plant metacaspases mediate immune response following activation by Ca2+. Here, via crystallography and functional analyses, the authors show that a linker domain in Arabidopsis Metacaspase 4 blocks substrate access to the active site but is cleaved multiple times in the presence of Ca2+ to allow enzyme activation.