Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer
oleh: Rui Xing, Yong Zhou, Jun Yu, Yingyan Yu, Yongzhan Nie, Wen Luo, Chao Yang, Teng Xiong, William K. K. Wu, Zhongwu Li, Yang Bing, Shuye Lin, Yaping Zhang, Yingqi Hu, Lin Li, Lijuan Han, Chen Yang, Shaogang Huang, Suiping Huang, Rui Zhou, Jing Li, Kaichun Wu, Daiming Fan, Guangbo Tang, Jianhua Dou, Zhenggang Zhu, Jiafu Ji, Xiaodong Fang, Youyong Lu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Structural variations in gastric cancer impact progression. Here, the authors perform whole-genome sequencing on 168 gastric cancer patients and identified tandem-duplications of super-enhancer ZFP36L2 in 10% of gastric cancer, and mutational signatures in tumors with cadherin 1 mutations that associated with poor prognoses.