Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules
oleh: Elisabeth H. Vollmann, Kristin Rattay, Olga Barreiro, Aude Thiriot, Rebecca A. Fuhlbrigge, Vladimir Vrbanac, Ki-Wook Kim, Steffen Jung, Andrew M. Tager, Ulrich H. von Andrian
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
T cells are selected in the thymus, through interaction with self-antigens, to remove autoreactive cells. Here the authors show that a specialized thymic dendritic cell subset juxtaposes to microvessels, requires CX3CR1/CX3CL1 for this positioning, and has processes extruding into the blood stream to sample soluble macromolecules and assist in T cell selection.