T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology
oleh: Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-07-01 |
Deskripsi
Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype. This approach allowed to identify that secondary genomic alterations, like Notch1 mutations, appeared late and only took place within the thymus during T-ALL development. These concepts are therefore critical for the development of modern therapies aimed at curing T-ALL.