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Breast abscess usually occurs during lactation and the responsible organism is often <i>S.Aureus</i>. Breast abscess in non-lactating women is extremely rare and limited data is available in the literature regarding this entity. In our study, a 36-year-old non-lactating female patient who developed bilateral breast abscess due to <i>E.coli</i> infection without any predisposing factors has been discussed in light of the literature.