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We experimentally studied the air–water pressure drop characteristics with inner diameters of 20 mm under stable and transverse vibration conditions in the horizontal circular channel. We experimented with the status of the gas-phase conversion flow velocity <i>J_g</i> at 0.1–20 m/s, and the liquid-phase conversion flow velocity <i>J_w</i> at 0.1–3.0 m/s. In this paper, we discuss the effect of flow velocity, amplitude, and frequency on the transverse vibration pressure drops. With increasing frequency and amplitude, the vibration performance of pressure drops become more intense. Thus, with increasing frequency and amplitude, the frictional pressure drop increases. Moreover, the frictional pressure drop increases linearly with the increasing flow velocity. We compared the experimental results of air–water pressure drop with the calculated results of previous empirical correlations. Based on Chisholm-C correlation, we obtained a modified correlation for factor C in horizontal channels under transverse vibration conditions. The new correlation considers the effect of channel confinement number, amplitude, frequency, and vapor quality. The new correlation has relatively good prediction results for the experiments, and the mean absolute deviation is 8.2%.