Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes
oleh: Casey E. Romanoski, Xinshuai Qi, Shreya Sangam, Rebecca R. Vanderpool, Robert S. Stearman, Austin Conklin, Manuel Gonzalez-Garay, Franz Rischard, Ramon J. Ayon, Jian Wang, Tatum Simonson, Aleksandra Babicheva, Yinan Shi, Haiyang Tang, Ayako Makino, Yogendra Kanthi, Mark W. Geraci, Joe G.N. Garcia, Jason X.-J. Yuan, Ankit A. Desai
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2020-11-01 |
Deskripsi
Using RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.