Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions

oleh: Lucio Manzi, Andrew S. Barrow, Daniel Scott, Robert Layfield, Timothy G. Wright, John E. Moses, Neil J. Oldham

Format: Article
Diterbitkan: Nature Portfolio 2016-11-01

Deskripsi

Mapping protein-ligand interactions is fundamental to advance the understanding of cellular processes and to develop drug discovery strategies. Here, the authors present a photo-activated probe that allows highly efficient labelling and identification of protein binding sites using mass spectrometry.