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Objective To investigate the changes and immune mechanisms of peripheral blood lymphocyte subsets in psoriasis patients with progressive, stationary and regression stages. Methods The percentage of lymphocytes in each group of peripheral blood mononuclear cells (PBMCs) in 77 patients with psoriasis vulgaris including 28 patients during progression, 23 patients during stationary, and 26 patients during regression. Results The percentages of CD3+, CD4+ and CD8+ lymphocytes were significantly increased in both the progression and stationary stages as compared to the regression stage (P＜0.01). CD4- and CD8- subsets in the peripheral blood lymphocyte subsets of the patients showed a decreasing trend according to progression, stationary and regression stages(P＜0.05). The result showed that the proportion of CD3-CD16+CD56+ increased with the stability of the disease, the proportion of CD45+CD14+ gradually decreased, and the proportion of CD3-CD19+ was negatively correlated with the disease (P＜0.05). Conclusions There are significant differences in lymphocyte subsets in the three groups of patients with psoriasis, which further supported the immune pathogenesis of psoriasis.