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Blepharokeratoconjunctivitis(BKC)refers to a group of inflammatory lesions secondary to chronic blepharitis in cornea and(or)conjunctiva, is very common in clinic. At the same time, this kind of disease is easily misdiagnosed and missed diagnosed, which causing the management of patient were delayed. The characteristic of BKC is that the patient's condition is prolonged unhealed and unreasonable treatment can result in irreversible damage to the visual function of the patient. In recent years, with the public's understanding of ocular surface diseases has deepened, they also emphasized the influence of BKC to eye health. Although a large number of clinical studies have been carried out on the diagnosis and treatment of BKC, at present there is no unified standard of diagnosis and treatment for it. Consulting the relevant literature and combined with current research status, the diagnosis and treatment of BKC are reviewed in this paper.