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<p>This study aims to compare the Introduction section of a number of medical research articles written by non-native speakers of English (Iranian) and English native speakers in terms of their rhetorical structures. The articles published in ISI-indexed journals have been investigated using the models presented by Nwogu and Halliday. The models are related to Moves/Sub-moves and grammatical metaphors, respectively. Using statistical tests such as chi-square tests for goodness of fit and Mann-Whitney U tests, the authors have found that the Iranians used fewer Moves/Sub-moves and grammatical metaphors compared to native speakers. Awareness of this academic writing practice may contribute to pave the ground for Iranian researchers to publish their articles in world-known journals.</p><p><strong>Keywords:</strong> genre, writing, research articles, SFL, ESP, ESL, grammatical metaphors.</p>