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Besides Hermitian systems, quantum simulation has become a strong tool to investigate non-Hermitian systems, such as PT-symmetric, anti-PT-symmetric, and pseudo-Hermitian systems. In this work, we theoretically investigate quantum simulation of an anti-<i>P</i>-pseudo-Hermitian two-level system in different dimensional Hilbert spaces. In an arbitrary phase, we find that six dimensions are the minimum to construct the anti-<i>P</i>-pseudo-Hermitian two-level subsystem, and it has a higher success probability than using eight dimensions. We find that the dimensions can be reduced further to four or two when the system is in the anti-PT-symmetric or Hermitian phase, respectively. Both qubit-qudit hybrid and pure-qubit systems are able to realize the simulation, enabling experimental implementations in the near future.