Applications of the Methylotrophic Yeast <i>Komagataella phaffii</i> in the Context of Modern Biotechnology
oleh: Lidia Maria Pepe de Moraes, Henrique Fetzner Marques, Viviane Castelo Branco Reis, Cintia Marques Coelho, Matheus de Castro Leitão, Alexsandro Sobreira Galdino, Thais Paiva Porto de Souza, Luiza Cesca Piva, Ana Laura Alfonso Perez, Débora Trichez, João Ricardo Moreira de Almeida, Janice Lisboa De Marco, Fernando Araripe Gonçalves Torres
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2024-06-01 |
Deskripsi
<i>Komagataella phaffii</i> (formerly <i>Pichia pastoris</i>) is a methylotrophic yeast widely used in laboratories around the world to produce recombinant proteins. Given its advantageous features, it has also gained much interest in the context of modern biotechnology. In this review, we present the utilization of <i>K. phaffii</i> as a platform to produce several products of economic interest such as biopharmaceuticals, renewable chemicals, fuels, biomaterials, and food/feed products. Finally, we present synthetic biology approaches currently used for strain engineering, aiming at the production of new bioproducts.