Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
oleh: Stanka Matic, Min Jiang, Thomas J. Nicholls, Jay P. Uhler, Caren Dirksen-Schwanenland, Paola Loguercio Polosa, Marie-Lune Simard, Xinping Li, Ilian Atanassov, Oliver Rackham, Aleksandra Filipovska, James B. Stewart, Maria Falkenberg, Nils-Göran Larsson, Dusanka Milenkovic
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
It has been debated whether premature ageing in mitochondrial DNA mutator mice is driven by point mutations or deletions of mtDNA. Matic et al generate Mgme1 knockout mice and show here that these mice have tissue-specific replication stalling and accumulate deleted mtDNA, without developing progeria.