Role of MR spectroscopy and diffusion-weighted imaging in diagnosis of orbital masses

oleh: Amina Ahmed Sultan, MagdaAli HanyAl-backry, Eman Mohamed Alhefney, Amany Ezzat Mosa, Heba Elmetwally Abdallah Farahat

Format: Article
Diterbitkan: SpringerOpen 2018-03-01

Deskripsi

Purpose: To assess the value of (MRI), (DWI) and (MRS) in the diagnosis of different orbital masses and differentiation between benign and malignant masses. Patients and methods: Sixty patients were enrolled in this study (31 females, 29 males, their ages ranged from 3 month to 75 years with mean age of 35.3 years). Clinical examination, (T1WI&T2WI) MRI and postcontrast T1WI, DWI, and MR Spectroscopy were done in all cases. Histopathological examination was done for 55 patients, and follow-up was done for 5 cases after medical treatment: two cases of pseudotumor and three cases of cellulites. Results: The study comprised 60 patients complaining of proptosis, swelling and diminution of vision. Thirty-three (55%) of patients had benign orbital masses and 27 (45%) patients had malignant orbital masses. The mean ADC value of malignant lesions was 0.89 ± 0.20. There was a statistically significant difference (p = ≤.001) between benign and malignant ADC values. The Mean Cho/Cr ratio for benign lesions was 1.19 ± 0.25 which showed statistically high significance (p = ≤.001∗∗) compared to Cho/Cr ratio of malignant lesions which was 2.44 ± 0.30.Diffusion-weighted MRI could differentiate between benign and malignant masses in 75% of cases. However, MRS could overcome this overlap and could differentiate benign from malignant tumors in 96% of scanned patients. Conclusion: Both DWI and MRS imaging are helpful tools in differentiating malignant orbital lesions from benign masses. Keywords: Magnetic resonance spectroscopy, MRI diffusion, Orbital lesions, Proptosis, Benign and malignant