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Enamel hypomineralization is characterized by decreased refractive index of the lesion surface as compared to the surrounding sound enamel. Icon® treatment has been recently successfully used for the cosmetic treatment of enamel demineralizations seen in white spot lesions (WSLs) and developmental defects of enamel (DDE). On the other hand, cases of molar incisal hypomineralization (MIH), deep lesions of traumatic origin, and those associated with severe fluorosis do not have the same response to this type of treatment. The application of a new deep Icon® infiltrative technique is proposed and the aesthetic results are validated by using a spectrophotometric approach as previously described by our group.