Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
oleh: Chon Phin Ong, Kaiming Tang, Pak-Hin Hinson Cheung, Hongzhuo Zhang, Tze-Tung Tang, Yaqian Xue, Junjue Wang, Kelvin Kai-Wang To, Shuofeng Yuan, Zi-Wei Ye, Dong-Yan Jin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-11-01 |
Deskripsi
Abstract We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.