Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis
oleh: Jiahui Cao, Manuel Ehling, Sigrid März, Jochen Seebach, Katsiaryna Tarbashevich, Tomas Sixta, Mara E. Pitulescu, Ann-Cathrin Werner, Boris Flach, Eloi Montanez, Erez Raz, Ralf H. Adams, Hans Schnittler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-12-01 |
Deskripsi
The formation of new blood vessels requires both polarized cell migration and coordinated control of endothelial cell contacts. Here, Cao and colleagues describe at the sub-cellular level the cytoskeletal and cell junction dynamics regulating these processes upon VEGF-induced cell elongation.