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Pulmonary actinomycosis is usually occured as a result of aspiration of the organism contained in the oropharingeal secretions. It could cause a pulmonary mass, pneumonia or pleural involvement and also rarely an endobronchial lesion. A 63 year old nonsmoker male patient admitted our clinic with complaints of dry cough, dyspnea and wheezing which have been continiuing for 6 months. The patient with type 2 diabetes mellitus for 15 years had a partial collapse in right middle lobe and elevation at right diafragma contour in computerized tomography of the thorax . An endobronchial lesion in the intermediate bronchi was viewed with fiberoptic bronchoscopy. Biopsy result showed no finding of malignancy, colonies of actinomycosis were seen. As a result of oral penicillin based antibiotic therapy for 21 days, radiological and clinical regression were detected. A prominent regression was seen in the lesions at control bronchoscopy.As a result, for the differantial diagnosis of endobronchial lesions, especially if immunosupressive disease is present, fungal infections should also be kept in mind. [Cukurova Med J 2014; 39(4.000): 946-949]