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Chinese jujube has been valued for its medical properties. To examine the beneficial role of jujube in regulating the immune response, we investigated the anti-allergic effects of jujube extract and cyclic adenosine monophosphate (cAMP), a functional compound of jujube extract, using a mouse allergy model and rat basophilic leukemia (RBL)-2H3 mast cells. The investigations of the immunomodulatory effects of jujube extract on RBL-2H3 mast cell degranulation showed that the release of β-hexosaminidase (β-hex) was inhibited. In mice with ovalbumin (OVA)-induced allergic rhinitis, cAMP reduced the secretion of IgE and histamine in the plasma. cAMP regulated both Th1 and Th2 cytokines levels in the plasma. In addition, cAMP inhibited β-hex release and blocked extracellular Ca2+ influxes in RBL-2H3 cells. Our results demonstrate that jujube, as well as cAMP, suppressed cytokine production in the allergic response pathway, which resulted in prevention or alleviation of allergy symptoms.