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Argonaute2 (AGO2) is an important protein connecting the construction of RNA-induced silencing complex (RISC) and micro-RNA (miRNA) biogenesis. This paper explores the mechanism during the function through previous studies which reveal the crystal structure and affinity comparisons. It is concluded that the AGO2 have compartmentalized domains for certain functions, which have both individual and cooperative role in the entire process. The characters of AGO2 and miRNA suggest a model of regiondifferent nucleotide chains in miRNA, which means its epigenetic information is based on base sequence and its special information. According to these findings, further studies are advised to monitor the reactions in a dynamical method, which would be a new potential entry point for clinical utilization.