RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
oleh: Philip East, Gavin P. Kelly, Dhruva Biswas, Michela Marani, David C. Hancock, Todd Creasy, Kris Sachsenmeier, Charles Swanton, TRACERx consortium, Julian Downward, Sophie de Carné Trécesson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other solid tumours, with improved performance over KRAS mutations alone.