High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury
oleh: Wei Li, Jian Chen, Shujie Zhao, Tianhe Huang, Huiyan Ying, Claudia Trujillo, Giuseppina Molinaro, Zheng Zhou, Tao Jiang, Wei Liu, Linwei Li, Yuancheng Bai, Peng Quan, Yaping Ding, Jouni Hirvonen, Guoyong Yin, Hélder A. Santos, Jin Fan, Dongfei Liu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
High drug loading improves therapeutic efficacy and reduces side effects in drug delivery. Here, the authors use controlled diffusion of solvents to precipitate drug nanoparticles in polymer particles while the polymer is solidifying and demonstrate the particles for drug delivery in a spinal cord injury model.