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This study analyzed the manufacturing implemented different modes of innovation at different regions, and established a model to predict the likelihood that the enterprise would follow the innovation mode dominated by the local government. Governmental regulation of innovation and spurring enterprises to innovate were important tools for development of the manufacturing in China, but regional differences in economic development required different coupling strategies of innovation. The results revealed that the developed region in China was biased to undertake disruptive innovation, while the developing region drived incremental innovation mainly, and made a theoretical model to explore the probability respectively. We assigned corresponding values based on theoretical analysis and relevant assumptions, and discovered that in the developing region was more likely to follow the innovation mode proposed by the local government than that in the developed region, but the data demonstrated that the probability were comparatively small for both the developed region and the developing region.