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This paper presents the application of the mathematical modeling to such a specific area as environ-economical interaction in prospect of big countries like India. A model of mutual interaction of dirty drinking water resulting water borne diseases, badly affected economy is proposed. For the description of some of these models illustrates drinking water resources, incapable municipal water treatment consequently expansion of diseases, World Bank loan, affected biggest labour forces (mankind) and ultimate results in the form of decrease in GDP. These mathematical models may be used in the solving of similar type problems exist in south and eastern Asian economies.