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A status report is presented about the Nanoplasmonic Laser Induced Fusion Experiment (NAPLIFE). The goal is to investigate and verify plasmonically enhanced phenomena on the surfaces of nanoantennas embedded in a polymer target at laser intensities up to a few times <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mn>10</mn><mn>16</mn></msup></semantics></math></inline-formula> W/cm<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow></mrow><mn>2</mn></msup></semantics></math></inline-formula> and pulse durations of 40–120 fs. The first results on enhanced crater formation for Au-doped polymer targets are shown, and SERS signals typical for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>CD</mi><mn>2</mn></msub></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>ND</mi></semantics></math></inline-formula> bound vibrations are cited. Trials to detect <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi mathvariant="normal">D</mi><mo>/</mo><mi mathvariant="normal">H</mi></mrow></semantics></math></inline-formula> ratio by means of LIBS measurments are reported. Plasmonics has the potential to work at these intensities, enhancing the energy and deuterium production, due to thus far unknown mechanisms.