Effectiveness of the ChAdOx1 nCoV-19 Coronavirus Vaccine (Covishield<sup>TM</sup>) in Preventing SARS-CoV2 Infection, Chennai, Tamil Nadu, India, 2021
oleh: Sharan Murali, Manikandanesan Sakthivel, Kamaraj Pattabi, Vettrichelvan Venkatasamy, Jeromie Wesley Vivian Thangaraj, Anita Shete, Alby John Varghese, Jaganathan Arjun, Chethrapilly Purushothaman Girish Kumar, Pragya D Yadav, Rima Sahay, Triparna Majumdar, Manisha Dudhmal, Azhagendran Sivalingam, Sudha Rani Dhanapal, Augustine Durai Samy, Vijayaprabha Radhakrishnan, Murali Mohan Muni Krishnaiah, Suresh Arunachalam, Punita Muni Krishna Gandhi, Elavarasu Govindasamy, Prabhakaran Chinnappan, Dhana Priya Vadhani Sekar, Prakash Marappan, Ezhil Pounraj, Parasuraman Ganeshkumar, Murugesan Jagadeesan, Manish Narnaware, Gagandeep Singh Bedi, Prabhdeep Kaur, Manoj Murhekar
| Format: | Article |
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| Diterbitkan: | MDPI AG 2022-06-01 |
Deskripsi
We estimated the effectiveness of two doses of the ChAdOx1 nCoV-19 (Covishield) vaccine against any COVID-19 infection among individuals ≥45 years in Chennai, Tamil Nadu, India. A community-based cohort study was conducted from May to September 2021 in a selected geographic area in Chennai. The estimated sample size was 10,232. We enrolled 69,435 individuals, of which 21,793 were above 45 years. Two-dose coverage of Covishield in the 18+ and 45+ age group was 18% and 31%, respectively. Genomic analysis of 74 out of the 90 aliquots collected from the 303 COVID-19-positive individuals in the 45+ age group showed delta variants and their sub-lineages. The vaccine’s effectiveness against COVID-19 disease in the ≥45 age group was 61.3% (95% CI: 43.6–73.4) at least 2 weeks after receiving the second dose of Covishield. We demonstrated the effectiveness of two doses of the ChAdOx1 vaccine against the delta variant in the general population of Chennai. We recommend similar future studies considering emerging variants and newer vaccines. Two-dose vaccine coverage could be ensured to protect against COVID-19 infection.