Find in Library

<p>Abstract</p> <p>Background</p> <p>The aims of this study were to determine the accuracy of concurrent core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB) for breast lesions and to estimate the false-negative rate using the two methods combined.</p> <p>Methods</p> <p>Over a seven-year period, 2053 patients with sonographically detectable breast lesions underwent concurrent ultrasound-guided CNB and FNAB. The sonographic and histopathological findings were classified into four categories: benign, indeterminate, suspicious, and malignant. The histopathological findings were compared with the definitive excision pathology results. Patients with benign core biopsies underwent a detailed review to determine the false-negative rate. The correlations between the ultrasonography, FNAB, and CNB were determined.</p> <p>Results</p> <p>Eight hundred eighty patients were diagnosed with malignant disease, and of these, 23 (2.5%) diagnoses were found to be false-negative after core biopsy. After an intensive review of discordant FNAB results, the final false-negative rate was reduced to 1.1% (<it>p-value = </it>0.025). The kappa coefficients for correlations between methods were 0.304 (<it>p-value </it>< 0.0001) for ultrasound and FNAB, 0.254 (<it>p-value </it>< 0.0001) for ultrasound and CNB, and 0.726 (<it>p-value </it>< 0.0001) for FNAB and CNB.</p> <p>Conclusions</p> <p>Concurrent CNB and FNAB under ultrasound guidance can provide accurate preoperative diagnosis of breast lesions and provide important information for appropriate treatment. Identification of discordant results using careful radiological-histopathological correlation can reduce the false-negative rate.</p>