Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
oleh: Juliana Inoue, Miguel Silva, Bakary Fofana, Kassim Sanogo, Andreas Mårtensson, Issaka Sagara, Anders Björkman, Maria Isabel Veiga, Pedro Eduardo Ferreira, Abdoulaye Djimde, José Pedro Gil
| Format: | Article |
|---|---|
| Diterbitkan: | Centers for Disease Control and Prevention 2018-08-01 |
Deskripsi
Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as an antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.