Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling
oleh: Xiaoming Ren, Amy D. Gelinas, Ira von Carlowitz, Nebojsa Janjic, Anna Marie Pyle
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-10-01 |
Deskripsi
The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that this aptamer inhibits the IL-1α signaling pathway.