Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids
oleh: Syeda Laila Rubab, Bushra Nisar, Abdul Rauf Raza, Nisar Ullah, Muhammad Nawaz Tahir
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2013-12-01 |
Deskripsi
Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively.