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Knowledge discovery in multiple databases offers many opportunities and challenges. We have given a number of motivating points on knowledge discovery in multiple databases. In view of further studies on this aspect, we highlight some domains that generated numerous problems on multiple related databases. Activities related to data preprocessing in a multi-database mining environment are also discussed. Important techniques of mining multiple databases are outlined. Many interesting patterns that originated out of multi-database environments are highlighted. We shall witness more research outcomes and investigations as the number of multi-database domains is on the rise.