Genome-guided discovery of cancer therapeutic targets

oleh: Prathyusha Konda, Simon Garinet, Eliezer M. Van Allen, Srinivas R. Viswanathan

Format: Article
Diterbitkan: Elsevier 2023-08-01

Deskripsi

Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances in genomics and functional genetics have enabled the unbiased discovery of novel molecular targets at scale. We summarize the promise and challenges in integrating genomic and functional genetic landscapes of cancer to establish the next generation of cancer targets.