BEARscc determines robustness of single-cell clusters using simulated technical replicates
oleh: D. T. Severson, R. P. Owen, M. J. White, X. Lu, B. Schuster-Böckler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-03-01 |
Deskripsi
Single cell messenger RNAseq allows the study of heterogeneity in tissue samples. Here the authors present BEARscc, a tool that uses RNA spike-in controls to simulate experiment-specific technical replicates to estimate the robustness of computational predictions of subpopulations of cells.