Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice
oleh: Zhengpin Wang, Xiaojiang Xu, Jian-Liang Li, Cameron Palmer, Dragan Maric, Jurrien Dean
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
Spermatogonial stem cells have the dual capacity to self-renew and differentiate into mature spermatozoa. Here, using transcriptome analyses of juvenile testes in gene-edited mice, the authors demonstrate that PRAMEF12 is required to maintain germ cell homeostasis and promote their differentiation.