Case report: A case of rare metastasis of gastric cancer to the axillary lymph node metastasis treated with combination immunotherapy
oleh: Jin Wang, Jin Wang, Jin Wang, Yu Cheng, Yu Cheng, Yu Cheng, Yulin Wang, Yulin Wang, Yulin Wang, Hengxin Liu, Hengxin Liu, Hengxin Liu, Shuang Wu, Shuang Wu, Shuang Wu, Guangwei Tian, Jinglei Qu, Jinglei Qu, Jinglei Qu, Xiujuan Qu, Xiujuan Qu, Xiujuan Qu
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2024-02-01 |
Deskripsi
Lymph node (LN) metastasis is a common mode of metastasis in advanced gastric cancer (GC), while axillary LN metastasis infrequently occurs in GC. There are few reports on this rare type of metastasis – especially its clinicopathological features – and systemic treatment are unclear. We describe a case of GC with extensive metastasis, including the rare axillary LN metastasis. The patient achieved partial response of optimal efficacy, who was treated with combination immunotherapy as second-line treatment for nearly two years. The potential mechanisms were revealed by clinical and immune characteristics, such as high expression of PD-L1, high tumor mutational burden (TMB-H), Epstein-Barr virus (EBV) positive and CD8+ tumor-infiltrating lymphocyte positive.