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Six dogs with hernia on ventral abdomen were surgically treated by hernioplasty using decellularised bovine pericardium. The dogs were having hernia as congenital condition. The animals and on clinical, hematological and biochemical evaluation, animals were confirmed fit for surgery. Under general anaesthesia surgical correction of the hernia was performed, after reduction of hernial contents, the defect was corrected by hernioplasty using decellularised bovine pericardium as an inlay graft. During an observation period of 60 days the physiological, haematological and biochemical parameters showed variations within the normal range except for C-reactive protein in the immediate post-operative period