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The current COVID-19 epidemic situation is grim, and the government has realized the importance of biosafety. This paper summarizes the situation and experience of biosafety management and education in pathogenic biology teaching laboratory from the aspects of management system, hardware construction and software construction. And through the questionnaire survey of the eight-year clinical students in Shanghai Jiao Tong University School of Medicine, we have a preliminary understanding of the students' views on the way of learning biosafety knowledge and the situation of mastering biosafety knowledge. It is expected that through the consideration of biosafety education, the curriculum design of biosafety education of pathogenic biology will be discussed to improve the knowledge level of biosafety of medical students.